At least 20 shots were fired at Bell Tower Shops in Fort Myers at 4.30am this morning.
Cops locked down the area as they hunt for the attacker.
Officers confirmed two people were pronounced dead at the scene.
"Multiple" more casualties were rushed to a local hospital for treatment.
It is not known what sparked the shoot-out.
"It does not appear to be a random act of violence," Lee County Sheriff Carmine Marceno said from the scene.
He gave no further information and none of the victims have been identified.
A woman told local radio WBBH that her son was killed and husband shot.
The witness told reporters she was at a restaurant on the retail park celebrating her birthday when shots rang out.
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