The Met Office issued 14 weather warnings on Sunday as forecasters warn of "danger to life".
A "500 mile curtain of snow" is hitting the UK, with warnings for freezing rain issued for most of the country.
This morning, Police Scotland said there have already been several accidents on the M74, and warned motorists to avoid the "treacherous" A9.
The Met Office has issued multiple Amber weather warnings across most of Scotland, Northern and Central England for freezing rain – a rare phenomenon where ice sheets known as black ice instantly form on road surfaces.
A fourth Amber warning for heavy snow and blizzards was also released yesterday for Scotland as areas barely reach temperatures past freezing.
Ten yellow warnings are also in place – forecasting snow, strong winds and heavy rain to hit most regions of Scotland, Wales and the Yorkshire and Humber area.
Up to 15 inches of snow is expected to fall on the highest peaks in Scotland, while eight inches will hit lower ground.
Met Office warnings remain in place until Sunday morning.
Superintendent Louise Blakelock, Deputy Head of Road Policing for Police Scotland, said: “Following warnings issued by the Met Office, there is a high risk of disruption to road journeys in all areas of mainland Scotland.
"Freezing rain is highly unusual and is expected to result in the rapid development of widespread ice, which will lead to dangerous travelling conditions.
"Congestion caused by all vehicles may restrict the emergency services, recovery vehicles, gritters and snowploughs from providing essential assistance or from clearing roads.