The baby is in a critical condition as cops desperately hunt the knifeman in Feltham, West London.
The Metropolitan Police confirmed the mum in her 30s and child were seriously hurt by someone "known" to them and no arrests had been made.
Witnesses reported seeing about 50 officers swarming the area near Swinfield Close as they traced a man living at the home they were found in.
The Oriel estate was said to be on lockdown as a helicopter circled above looking for the knifeman.
More than 20 police cars reportedly descended on the area near Hounslow Road as residents said they have been told to stay inside.
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One person told Get West London: "We have been told by police to stay in and lock doors. The estate is taped off, and an armed response is present."
A Met spokeswoman said: "Police were called to a residential address at Swinfield Close, Hanworth at 1912hrs on Monday, 4 June to reported concerns for safety.
"Officers and London Ambulance Service and London’s Air Ambulance attended. At the scene a woman and an infant [no further details] had suffered stab wounds.
"Both victims were taken to a west London hospital where their conditions are serious but stable at this time. We await further updates.
"A crime scene has been established and officers remain at the scene.
"Hounslow Police investigate. No arrests. Enquiries continue."
One person tweeted: "About 8 or so police cars and a few ambulances heading #Feltham way doesn't look good."
Another added: "Whole middle road cut off from the community centre. About 50 coppers undercover, armed and uniform."
It comes days after a man was stabbed less than two miles away.
Armed police patrolled the area after a man was said to be wielding a machete.
Knife crime has soared in the UK with at least 37 people have been fatally stabbed – and 62 overall killed – in London since the beginning of the year.
Met Police records show 37, 443 recorded knife offences and 6,694 recorded gun offences across the UK in the year up to September 2017.
In London, the problem was even more pronounced than the rest of the country, with 12,980 knife crimes taking place in the capital – 2,452 more than the equivalent year.
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